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A polysaccharide from Sargassum fusiforme protects against immunosuppression in cyclophosphamide-treated mice.
浏览次数:2112   来源:未知    作者:未知  发布时间:2012-06-28  返回

 Chen X, Nie W, Fan S, Zhang J, Wang Y, Lu J, Jin L.

Source

Institute of Glycobiological Engineering/School of Laboratory Medicine & Life Science, Wenzhou Medical College, Wenzhou 325035, China.

Abstract

A water-soluble polysaccharide (SFPS) isolated from Sargassum fusiforme was purified by DEAE-52 cellulose anion-exchange and Sephadex G-200 gel filtration chromatography. The high performance gel permeation chromatography (HPGPC) analysis showed that the average molecular weight (Mw) of SFPS was 299kDa. The SFPS was composed of d-fucose, l-xylose, d-mannose and d-galactose in a molar ratio of 5.9:1.0:2.3:2.2. The results showed that SFPS stimulated proliferation and the cytokines (IL-2, IL-6 and IFN-γ) secretion of splenic lymphocytes in cyclophosphamide-induced immunosuppressed mice. SFPS markedly increased the phagocytic rates and cytokines (IL-2, IL-6 and TNF-α) secretion of peritoneal macrophages. Administration of SFPS significantly raised spleen index. It could act as an efficacious adjacent immunopotentiating therapy or an alternative means in lessening chemotherapy-induced immunosuppression, and also can be utilized as immunostimulants for food and pharmaceutical industries.

Copyright © 2012 Elsevier Ltd. All rights reserved.

PMID:
 
22840047
 
[PubMed - in process]
 
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